Frequen-ZZZ® is an investigational device utilizing proprietary transspinal magnetic field technology designed to modulate the vagal regulatory network through spinal–autonomic coherence during sleep. By delivering spatially distributed, nanotesla-scale radio-frequency magnetic gradients along the cervical and thoracolumbar spine, the system aims to enhance parasympathetic activity and support restorative sleep physiology.

A double-blind, randomized, controlled proof-of-concept clinical study was initiated by Kunasan Inc. in collaboration with The Pennsylvania State University. The trial began in July 2023, with final data collection completed on May 10, 2024.  

Participants were enrolled based on an Insomnia Severity Index (ISI) ≥ 8, targeting individuals with clinically significant sleep disruption. This study was designed to evaluate whether nightly transspinal vagal modulation can improve objective and subjective markers of sleep quality while maintaining an excellent safety and tolerability profile.